A Perfect Weekend: 48 Hours in Biloxi, MS
Biloxi, often called the Coastal Heart of Mississippi, is located in Harrison County along the Gulf Coast in southern Mississippi. It is one of the oldest cities in the United States, founded in 1699 by French colonists, making it the first French settlement in the Mississippi Valley.
Today, Biloxi is a major tourist destination known for its white-sand beaches, fresh seafood, coastal culture, vibrant nightlife, casinos, shrimping industry, and diverse attractions. From the historic Biloxi Lighthouse and Beauvoir estate to Biloxi Beach and the Ohr-O’Keefe Museum of Art, the city offers something for every type of traveler.
Looking for the perfect 48-hour Biloxi itinerary? This 2-day guide covers the city’s top attractions, dining spots, nature areas, and historical landmarks to help you make the most of your visit.
Day One - Morning
8:00 AM – Breakfast at The Greenhouse on Porter
Start your first morning in Biloxi at The Greenhouse on Porter, a bright and welcoming café known for its rotating biscuit menu. Popular options include the King Cake Biscuit, biscuit sammies, egg plates, parfaits, biscuit and lox, sweet potato biscuits, avocado toast, and the baker’s breakfast. Drink choices include premium teas, cold brews, and creative lattes like the Orange Creamsicle Latte and the Biloxi Fog, making it a favorite stop for both locals and visitors.
11:00 AM – Visit the Biloxi Lighthouse
Next, head to the Biloxi Lighthouse, one of the city’s most photographed landmarks. Built in 1848, this cast-iron lighthouse sits beside Highway 90 and rises 65 feet above the ground. Guided tours take visitors up 57 spiral steps and a short ladder to the light room, where you can enjoy wide views of the Mississippi Sound and the Biloxi skyline. Along the way, you’ll see waterline markers from past hurricanes and learn about the lighthouse’s unique history, including the long period when it was maintained by female keepers.
Afternoon
12:00 PM – Maritime and Seafood Industry Museum
Continue your day at the Maritime and Seafood Industry Museum, which showcases Biloxi’s deep connection to shrimping, fishing, and oystering. The museum features interactive exhibits, full-scale schooner replicas, historic photographs, and displays about boat building and coastal crafts. One of the highlights is the Wade Guice Hurricane Museum, which uses immersive displays to tell the story of major Gulf Coast storms.
1:30 PM – Lunch at Mary Mahoney’s Old French House
For lunch, visit Mary Mahoney’s Old French House, one of the most famous and historic restaurants in Biloxi. Housed in one of the oldest buildings in the country, the restaurant is known for its elegant dining rooms, charming courtyard, and classic Southern and Gulf Coast cuisine. Menu favorites include seafood gumbo, charbroiled oysters, shrimp and grits, stuffed flounder, seafood Bienville, and shrimp and crab au gratin.
3:30 PM – Visit Beauvoir
Spend the afternoon at Beauvoir, the former home of Confederate President Jefferson Davis and now a National Historic Landmark. The 19th-century home features broad porches, coastal views, and a distinctive raised cottage style. Visitors can tour the restored house, explore the Jefferson Davis Presidential Library, walk through the gardens, and visit the museum exhibits. Guided tours are offered from 10 AM to 4 PM.
Evening
7:00 PM – Dinner at The Shed BBQ & Blues Joint
In the evening, head to The Shed BBQ & Blues Joint, a lively and rustic restaurant known for its slow-smoked meats cooked over pecan wood. The menu includes brisket, pulled pork, baby back ribs, sausages, smoked turkey, and BBQ wings, all served with classic Southern sides. Live blues music on weekends adds to the fun, relaxed atmosphere.
8:30 PM – Visit the Casinos
After dinner, continue your night at Hard Rock Biloxi. The casino offers live music, energetic bars, and hundreds of slot machines, along with table games such as Blackjack, Roulette, Craps, Baccarat, Mississippi Stud, and Ultimate Texas Hold’em.
Day Two - Morning
8:00 AM – Breakfast at Toasted Yolk Café
Start your second day at the Toasted Yolk Café in downtown Biloxi. The menu includes hearty breakfast plates such as the Cowboy Scramble, Yolkwich sandwiches, pork chop breakfast, and classic ham and eggs, along with sweet options like pancakes, granola apple French toast, and churro-style donuts.
10:00 AM – Visit Biloxi Beach
Spend the late morning relaxing at Biloxi Beach along the Mississippi Sound. The calm waters are ideal for swimming and paddleboarding, while the wide sandy shoreline is perfect for walking, sunbathing, photography, and beachcombing. Fishing from the shore or nearby piers is also popular.
Afternoon
1:00 PM – Lunch at The Blind Tiger
Enjoy lunch at The Blind Tiger, a lively beachside restaurant known for its mix of seafood and comfort food. The menu includes items like shrimp ceviche, smoked tuna dip, redfish pasta, Gulf shrimp tacos, fried catfish, burgers, and gumbo. The pet-friendly patio and waterfront views make it a great place to relax.
3:00 PM – Keesler Federal Park
In the afternoon, visit Keesler Federal Park, formerly MGM Park, home of the Double-A Biloxi Shuckers. Opened in 2015, the stadium features modern seating, walking paths, play areas, and community spaces, making it a pleasant place to stroll even when there isn’t a game.
5:00 PM – Ohr-O’Keefe Museum of Art
Later in the afternoon, explore the Ohr-O’Keefe Museum of Art, which celebrates the ceramics of George E. Ohr, known as the “Mad Potter of Biloxi,” along with rotating exhibitions of modern and historical art. The museum, designed by architect Frank Gehry, sits beneath oak trees along the Mississippi Sound and is a Smithsonian Affiliate.
Evening
7:00 PM – Dinner at Woody’s Roadside Biloxi
For dinner, stop at Woody’s Roadside Biloxi, a casual, family-friendly spot serving burgers, tacos, salads, and creative appetizers like Cheese Bombs and Big-Style Nachos.
8:30 PM – Nightcap at Fly Llama Brewing
End your trip at Fly Llama Brewing, a popular craft brewery near the ballpark offering a rotating selection of beers and hard seltzers in a relaxed and friendly setting.
Make your Biloxi trip easy and affordable. Book your room at Flamingo Beach Inn and enjoy a convenient location near the beach, casinos, and the city’s best attractions.
